ZBRK1 represses HIV-1 LTR-mediated transcription.

  title={ZBRK1 represses HIV-1 LTR-mediated transcription.},
  author={Hironori Nishitsuji and Makoto Abe and Reila Sawada and Hiroshi Takaku},
  journal={FEBS letters},
  volume={586 20},
The identification of cellular proteins that interact with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) provides a basic understanding of HIV-1 gene expression, which is the major determinant regulating virus replication. We show that ZBRK1 negatively regulates the HIV-1 LTR. Ectopic expression of ZBRK1 represses transcriptional activity of the HIV-1 LTR, whereas the depletion of endogenous ZBRK1 leads to activation of the HIV-1 LTR. The repressor activity of ZBRK1… CONTINUE READING