ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links

@article{Schellenberg2017ZATTR,
  title={ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links},
  author={Matthew J Schellenberg and Jenna Ariel Lieberman and Andr{\'e}s Herrero-Ruiz and Logan R Butler and Jason G Williams and Ana M Mu{\~n}oz-Cabello and Geoffrey A. Mueller and Robert E. London and Felipe Cort{\'e}s-Ledesma and R Scott Williams},
  journal={Science},
  year={2017},
  volume={357},
  pages={1412-1416}
}
Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by potent anticancer TOP2 drugs. How genotoxic TOP2 DNA-protein cross-links are resolved is unclear. We found that the SUMO (small ubiquitin-related modifier) ligase ZATT (ZNF451) is a multifunctional DNA repair factor that controls cellular responses to TOP2 damage. ZATT binding to TOP2cc facilitates a proteasome… CONTINUE READING
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