ZAP inhibits murine gammaherpesvirus 68 ORF64 expression and is antagonized by RTA.

@article{Xuan2013ZAPIM,
  title={ZAP inhibits murine gammaherpesvirus 68 ORF64 expression and is antagonized by RTA.},
  author={Yifang Xuan and Danyang Gong and Jing Qi and Chuanhui Han and Hongyu Deng and Guangxia Gao},
  journal={Journal of virology},
  year={2013},
  volume={87 5},
  pages={2735-43}
}
Zinc finger antiviral protein (ZAP) is an interferon-inducible host antiviral factor that specifically inhibits the replication of certain viruses, including HIV-1 and Ebola virus. ZAP functions as a dimer formed through intermolecular interactions of its N-terminal tails. ZAP binds directly to specific viral mRNAs and inhibits their expression by repressing translation and/or promoting degradation of the target mRNA. ZAP is not a universal antiviral factor, since some viruses grow normally in… CONTINUE READING

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