ZAP and ZIP, a Story to Forget

@article{Bliss2006ZAPAZ,
  title={ZAP and ZIP, a Story to Forget},
  author={Tim V. P. Bliss and Graham L. Collingridge and Serge Laroche},
  journal={Science},
  year={2006},
  volume={313},
  pages={1058 - 1059}
}
How are memories stored and retrieved? Long-awaited evidence shows directly that the strength of synaptic connections in hippocampal neurons underlies both processes. 

Paper Mentions

Vitamin A deficiency impairs postnatal cognitive function via inhibition of neuronal calcium excitability in hippocampus
J. Neurochem. (2012) 121, 932–943.
The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks.
TLDR
This work has shown that CA1 LTP and the accompanying memory processes can be dissociated, and in addition plastic events in several other brain regions are also necessary for memory formation of the one-trial task, and perhaps of many others. Expand
Brain Plasticity Mechanisms and Memory: A Party of Four
TLDR
While they have long been considered as alternative mechanisms of plasticity underlying the storage of long-term memories, recent evidence suggests that they are functionally linked, suggesting the mechanisms underlying plasticity in the brain required for the formation and retention of memories are multifaceted. Expand
Functional basis of associative learning and its relationships with long-term potentiation evoked in the involved neural circuits: Lessons from studies in behaving mammals
TLDR
This paper summarizes studies in behaving mammals carried out in the laboratory during the past ten years on the relationships between experimentally evoked long-term potentiation (LTP) and activity-dependent changes in synaptic strength taking place in hippocampal, prefrontal and related cortical and subcortical circuits during the acquisition of classical eyeblink conditioning or operant learning tasks. Expand
PKMζ, LTP Maintenance, and Long-Term Memory Storage
TLDR
This chapter reviews the current state of knowledge on PKMζ, focusing on its discovery and the elucidation of its unique structure as an autonomously active form of PKC, its function in LTP maintenance, and its role in normal memory storage and disorders of memory. Expand
ERK1/2 and CaMKII-mediated events in memory formation: Is 5HT regulation involved?
TLDR
The so far scanty, but significant, evidence for a role of 5HT in the regulation of CaMKII and MAPK is commented on. Expand
Long-term memory persistence
TLDR
A delayed post-training phase that induces memory persistence is described in rodents immediately after hippocampal cellular consolidation is over that has been suggested to pave the way for systems consolidation. Expand
A role for the spine apparatus in LTP and spatial learning
TLDR
Mice lacking spine apparatuses (synaptopodin-deficient mice) show deficits in LTP and impaired spatial learning supporting the involvement of the spine apparatus in synaptic plasticity. Expand
Plastic modifications induced by object recognition memory processing
TLDR
It is shown that OR memory consolidation is accompanied by transient potentiation in the hippocampal CA3-CA1 synapses, while reconsolidation of this memory requires a short-lasting phase of depotentiation that could account for its well described vulnerability. Expand
PINing for Things Past
TLDR
The transient inhibition of the brain-specific, constitutively active protein kinase C isoform PKMζ erases memories that are even months old, and new data suggest how the high abundance of PKMαζ can be maintained over long periods of time. Expand
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References

SHOWING 1-10 OF 14 REFERENCES
A synaptic model of memory: long-term potentiation in the hippocampus
TLDR
The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength. Expand
New Circuits for Old Memories The Role of the Neocortex in Consolidation
TLDR
The studies reviewed here represent the first exciting steps toward the understanding of the molecular, cellular, and systems mechanisms of how the brain stores the authors' oldest and perhaps most defining memories. Expand
Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
1. The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbitsExpand
Storage of Spatial Information by the Maintenance Mechanism of LTP
TLDR
It is shown that a cell-permeable PKMz inhibitor, injected in the rat hippocampus, both reverses LTP maintenance in vivo and produces persistent loss of 1-day-old spatial information, indicating that the mechanism maintaining LTP sustains spatial memory. Expand
Synaptic plasticity and memory: an evaluation of the hypothesis.
TLDR
It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency. Expand
Memory Formation: The Sequence of Biochemical Events in the Hippocampus and Its Connection to Activity in Other Brain Structures
TLDR
It is suggested that the hippocampal chain of events that underlies memory formation is linked to long-term storage elsewhere through activity-dependent changes in cell connectivity. Expand
Learning Induces Long-Term Potentiation in the Hippocampus
TLDR
It is found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo. Expand
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
TLDR
It is shown that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal, and Zif268 is essential for the transition from short-to-long-term synaptic plasticity and for the expression of long-term memories. Expand
Protein kinase Mζ is necessary and sufficient for LTP maintenance
TLDR
This work shows the constitutively active form of an atypicalprotein kinase C (PKC) isozyme, protein kinase M zeta (PKMζ), is necessary and sufficient for LTP maintenance. Expand
Involvement of the CA3–CA1 Synapse in the Acquisition of Associative Learning in Behaving Mice
TLDR
The responsivity of the CA3–CA1 synapse seems to be modulated during associative learning, and both processes are prevented by experimental LTP or NMDA-receptor inactivation. Expand
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