ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice.

Abstract

OBJECTIVE The spondyloarthritides share genetic susceptibility, interleukin-23 (IL-23) dependence, and the involvement of microbiota. The aim of the current study was to elucidate how host genetics influence gut microbiota and the relationship between microbiota and organ inflammation in spondyloarthritides. METHODS BALB/c ZAP-70(W163C) -mutant (SKG) mice… (More)
DOI: 10.1002/art.38773

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