ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

@article{Crespo2003ZAP70EA,
  title={ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.},
  author={Marta Crespo and Francesc Bosch and Neus Villamor and Beatriz Bellosillo and Dolors Colomer and Mar{\'i}a Rozman and S{\'i}lvia Marc{\'e} and Armando L{\'o}pez-Guillermo and Elies Campo and Emili Montserrat},
  journal={The New England journal of medicine},
  year={2003},
  volume={348 18},
  pages={1764-75}
}
BACKGROUND The mutational status of immunoglobulin heavy-chain variable-region (IgVH) genes in the leukemic cells of chronic lymphocytic leukemia (CLL) is an important prognostic factor in the disease. We investigated whether the expression of ZAP-70 by CLL cells correlated with the IgVH mutational status, disease progression, and survival. METHODS The expression of ZAP-70 was analyzed in T-cell and B-cell lines and in peripheral-blood samples from 56 patients with CLL with the use of flow… CONTINUE READING
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