ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia.

@article{Chen2008ZAP70EI,
  title={ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia.},
  author={Liguang Chen and Lang Huynh and John Apgar and Li Shen Tang and Laura Rassenti and Arthur Weiss and Thomas J. Kipps},
  journal={Blood},
  year={2008},
  volume={111 5},
  pages={2685-92}
}
We transduced chronic lymphocytic leukemia (CLL) cells lacking ZAP-70 with vectors encoding ZAP-70 or various mutant forms of ZAP-70 and monitored the response of transduced CLL cells to treatment with F(ab)(2) anti-IgM (anti-mu). CLL cells made to express ZAP-70, a kinase-defective ZAP-70 (ZAP-70-KA(369)), or a ZAP-70 unable to bind c-Cbl (ZAP-YF(292)) experienced greater intracellular calcium flux and had greater increases in the levels of phosphorylated p72(Syk), B-cell linker protein (BLNK… CONTINUE READING

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