Z-DNA: the long road to biological function

@article{Rich2003ZDNATL,
  title={Z-DNA: the long road to biological function},
  author={A. Rich and Shuguang Zhang},
  journal={Nature Reviews Genetics},
  year={2003},
  volume={4},
  pages={566-572}
}
Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient localized conformational change. Few laboratories worked on the biology of Z-DNA. However, the discovery that certain classes of proteins bound to Z-DNA with high affinity and great specificity indicated a biological role. The most recent data show that some of these proteins participate in the… Expand

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