Ypt/Rab GTPases regulate two intersections of the secretory and the endosomal/lysosomal pathways.

@article{Lipatova2014YptRabGR,
  title={Ypt/Rab GTPases regulate two intersections of the secretory and the endosomal/lysosomal pathways.},
  author={Zhanna Lipatova and Nava Segev},
  journal={Cellular logistics},
  year={2014},
  volume={4 3},
  pages={e954870}
}
A prevailing question in the Ypt/Rab field is whether these conserved GTPases are specific to cellular compartments. The established role for Ypt1 and its human homolog Rab1 is in endoplasmic reticulum (ER)-to-Golgi transport. More recently these regulators were implicated also in autophagy. Two different TRAPP complexes, I and III, were identified as the guanine-nucleotide-exchange factors (GEFs) of Ypt1 in ER-to-Golgi transport and autophagy, respectively. Confusingly, Ypt1 and TRAPP III were… CONTINUE READING