Ypt/Rab GTPases: principles learned from yeast.

@article{Lipatova2015YptRabGP,
  title={Ypt/Rab GTPases: principles learned from yeast.},
  author={Zhanna Lipatova and Adelaide U.P. Hain and Volodymyr Y. Nazarko and Nava Segev},
  journal={Critical reviews in biochemistry and molecular biology},
  year={2015},
  volume={50 3},
  pages={
          203-11
        }
}
Ypt/Rab GTPases are key regulators of all membrane trafficking events in eukaryotic cells. They act as molecular switches that attach to membranes via lipid tails to recruit their multiple downstream effectors, which mediate vesicular transport. Originally discovered in yeast as Ypts, they were later shown to be conserved from yeast to humans, where Rabs are relevant to a wide array of diseases. Major principles learned from our past studies in yeast are currently accepted in the Ypt/Rab field… CONTINUE READING

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