Younger birth cohort correlates with higher breast and ovarian cancer risk in European BRCA1 mutation carriers.

@article{Kroiss2005YoungerBC,
  title={Younger birth cohort correlates with higher breast and ovarian cancer risk in European BRCA1 mutation carriers.},
  author={Regina Kroiss and Verena Winkler and Diana Bikas and Elisabeth Fleischmann and Claudia Mainau and Florian Frommlet and Daniela Muhr and Christine Fuerhauser and Maria Tea and Barbara Bittner and Ernst Kubista and Peter J. Oefner and Peter Bauer and Teresa M.U. Wagner},
  journal={Human mutation},
  year={2005},
  volume={26 6},
  pages={583-9}
}
Mutations in the BRCA1 gene result in an elevated risk of breast cancer (BC) and ovarian cancer (OC). However, risk estimates vary depending on the study population and statistical methodology used, and there are indications that the birth cohort and location of the mutation influence cancer risk. We investigated the risks for BC and OC associated with BRCA1 mutations in a young cohort of female mutation carriers who were identified by molecular genetic testing and belonged to a genetically… CONTINUE READING

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