Young spontaneously hypertensive rats (SHRs) display prodromal schizophrenia-like behavioral abnormalities

  title={Young spontaneously hypertensive rats (SHRs) display prodromal schizophrenia-like behavioral abnormalities},
  author={S. T. Niigaki and F. F. Peres and Lizia Ferreira and T. Lib{\^a}nio and V. Ab{\'i}lio},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • S. T. Niigaki, F. F. Peres, +2 authors V. Abílio
  • Published 2019
  • Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • &NA; The Spontaneously Hypertensive Rat (SHR) strain has been suggested as an animal model of schizophrenia, considering that adult SHRs display behavioral abnormalities that mimic the cognitive, psychotic and negative symptoms of the disease and are characteristic of its animal models. SHRs display: (I) deficits in fear conditioning and latent inhibition (modeling cognitive impairments), (II) deficit in prepulse inhibition of startle reflex (reflecting a deficit in sensorimotor gating, and… CONTINUE READING
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