Young lives lost as B cells falter: what we are learning about antibody responses in malaria.

@article{Portugal2013YoungLL,
  title={Young lives lost as B cells falter: what we are learning about antibody responses in malaria.},
  author={S{\'i}lvia Portugal and Susan K Pierce and Peter D Crompton},
  journal={Journal of immunology},
  year={2013},
  volume={190 7},
  pages={3039-46}
}
Plasmodium falciparum malaria remains a major public health threat for which there is no licensed vaccine. Abs play a key role in malaria immunity, but Ab-mediated protection is only acquired after years of repeated infections, leaving children in endemic areas vulnerable to severe malaria and death. Many P. falciparum Ags are extraordinarily diverse and clonally variant, which likely contribute to the inefficient acquisition of protective Abs. However, mounting evidence suggests that there is… CONTINUE READING
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