Young environment reverses the declined activity of aged rat-derived endothelial progenitor cells: involvement of the phosphatidylinositol 3-kinase/Akt signaling pathway.

@article{Zhu2009YoungER,
  title={Young environment reverses the declined activity of aged rat-derived endothelial progenitor cells: involvement of the phosphatidylinositol 3-kinase/Akt signaling pathway.},
  author={Guangxu Zhu and Mingbao Song and Huxuan Wang and Gang Zhao and Zheng-ping Yu and Yangguang Yin and Xiaohui Zhao and Lan Huang},
  journal={Annals of vascular surgery},
  year={2009},
  volume={23 4},
  pages={519-34}
}
BACKGROUND Although age-related impairment of endothelial progenitor cells (EPCs) has been documented in recent studies, the detailed role of aging-induced environment in EPCs remains unclear. METHODS Two and 20 months old Sprague-Dawley female rats were used in the present study. EPCs isolated from young (YEPCs) and aged (AEPCs) rats were cultured with young or aged serum. EPC migration and proliferation were detected with a modified Boyden chamber and the MTT assay, respectively; EPC… CONTINUE READING

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