Young children with Velo-Cardio-Facial syndrome (CATCH-22). Psychological and language phenotypes

@article{Eliez2000YoungCW,
  title={Young children with Velo-Cardio-Facial syndrome (CATCH-22). Psychological and language phenotypes},
  author={Stephan Eliez and Francisco Palacio-Espasa and A Spira and Mireille Lacroix and C{\'e}cile Pont and F. Luthi and Christiane Robert-Tissot and Carl Feinstein and D F Schorderet and Stylianos E. Antonarakis and Bertrand G. Cramer},
  journal={European Child \& Adolescent Psychiatry},
  year={2000},
  volume={9},
  pages={109-114}
}
Abstract This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (<5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for individuals with this chromosomal deletion led us to examine the psychiatric and cognitive status of young children with VCFS.Our observations suggest a phenotype comprised of a… Expand
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  • K. Vrtička
  • Psychology
  • Folia Phoniatrica et Logopaedica
  • 2007
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Detailed clinical histories of two patients with velo-cardio-facial syndrome who developed a psychotic illness and one who was found to have dysmorphological features associated with VCFS are described, suggesting chromosome 22q11 as a possible candidate region for genetic studies of schizophrenia. Expand
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