You may have worked on more adaptive designs than you think.

@article{Coffey2015YouMH,
  title={You may have worked on more adaptive designs than you think.},
  author={Christopher S. Coffey},
  journal={Stroke},
  year={2015},
  volume={46 2},
  pages={
          e26-8
        }
}
  • C. Coffey
  • Published 1 February 2015
  • Psychology
  • Stroke
According to the clinicaltrials.gov (accessed March 29, 2014), there are >1500 open clinical trials in the field of stroke. During the design of a clinical trial, several important design decisions must be made. Although study success depends on their accuracy, there may be limited information to guide the decisions. Adaptive designs address this uncertainty by allowing a review of accumulating data during an ongoing trial, and modifying trial characteristics accordingly if the interim… 
2 Citations
Practical characteristics of adaptive design in phase 2 and 3 clinical trials
TLDR
The practical characteristics of adaptive design used in clinical trials are examined and are expected to be ethical, reflect real medical practice, increase the likelihood of research and development success and reduce the allocation of patients into ineffective treatment groups by the early termination of clinical trials.
Best (but oft-forgotten) practices: the multiple problems of multiplicity-whether and how to correct for many statistical tests.
  • D. Streiner
  • Mathematics
    The American journal of clinical nutrition
  • 2015
TLDR
How multiple tests lead to an inflation of the α level is discussed and the following different contexts in which multiplicity arises are explored: testing for baseline differences in various types of studies, having >1 outcome variable, conducting statistical tests that produce >1 P value, taking multiple "peeks" at the data, and unplanned, post hoc analyses.

References

SHOWING 1-4 OF 4 REFERENCES
Adaptive Designs in Clinical Drug Development—An Executive Summary of the PhRMA Working Group
TLDR
Three particular areas where it is felt that adaptive designs can be utilized beneficially are discussed: dose finding, seamless Phase II/III trials designs, and sample size reestimation.
Statistical Monitoring of Clinical Trials: A Unified Approach
TLDR
A General Framework for Monitoring Power: Conditional, Unconditional, and Predictive, and Historical Monitoring Boundaries.
Overview, hurdles, and future work in adaptive designs: perspectives from a National Institutes of Health-funded workshop
TLDR
The workshop offered a forum for participants to address issues of ADs that arise at the planning, designing, and execution stages of clinical trials, and to hear the perspectives of influential members of the clinical trials community.
Good Practices for Adaptive Clinical Trials in Pharmaceutical Product Development
TLDR
This article is a summary of good adaptive practices for the planning and implementation of adaptive designs compiled from experiences gained in the pharmaceutical industry for trial simulation, trial documentation, and data monitoring committees.