You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia

@article{Sehgal2015YouEW,
  title={You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia},
  author={Alison Sehgal and Heiko Konig and Daniel Ezra Johnson and Dan Feng Tang and Ravi K Amaravadi and Michael Boyiadzis and Michael T Lotze},
  journal={Leukemia},
  year={2015},
  volume={29},
  pages={517-525}
}
A deeper understanding of the role of autophagy, literally ‘self-eating’, in normal and cancer cell biology has emerged over the last few years. Autophagy serves as a vehicle for cells to respond to various stressors including genomic, hypoxic and nutrient stress, and to oppose mechanisms of ‘programmed’ cell death. Here, we review not only mechanisms of cell death and cell survival but also the early successes in applying autophagy inhibition strategies in solid tumors using the only currently… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

7-hydroxy-staurosporine, UCN-01, induces DNA damage response, and autophagy in human osteosarcoma U2-OS cells.

  • Journal of cellular biochemistry
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Phagocytosis of Candida albicans Inhibits Autophagic Flux in Macrophages

  • Oxidative medicine and cellular longevity
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 122 REFERENCES

Autophagy is a survival mechanism of acute myelogenous leukemia precursors during dual mTORC2/mTORC1 targeting.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2014

Similar Papers

Loading similar papers…