Yop fusions to tightly folded protein domains and their effects on Yersinia enterocolitica type III secretion.

@article{Lee2002YopFT,
  title={Yop fusions to tightly folded protein domains and their effects on Yersinia enterocolitica type III secretion.},
  author={Vincent Tsung-yeh Lee and Olaf Schneewind},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 13},
  pages={3740-5}
}
Yersinia enterocolitica organisms secrete Yop proteins via the type III pathway. Translational fusion of yop genes to ubiquitin or dihydrofolate reductase results in hybrid proteins that cannot be secreted. The folding of hybrids prevents their own transport, but it does not hinder the type III secretion of other Yops. 

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Translocation of a hybrid YopEadenylate cyclase from Yersinia enterocolitica into HeLa cells

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Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach

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