Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin.

@article{Kesteren2003YondelisE,
  title={Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin.},
  author={Charlotte van Kesteren and M M M de Vooght and Luis L{\'o}pez-L{\'a}zaro and Ron A. A. Math{\^o}t and Jan H. M. Schellens and Jos{\'e} Mar{\'i}a Jimeno and Jos H. Beijnen},
  journal={Anti-cancer drugs},
  year={2003},
  volume={14 7},
  pages={487-502}
}
Yondelis (trabectedin, ET-743) is a novel antitumor agent derived from a marine source, the Caribbean tunicate Ecteinascidia turbinata. Preclinical studies demonstrated activity at low concentrations against a variety of tumors. The mechanism by which ET-743 exerts its antitumor activity has not been completely elucidated yet. Binding to the minor groove of DNA which causes a bend towards the major groove has been demonstrated. Furthermore, ET-743 interferes with DNA binding proteins and… CONTINUE READING

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