Yokukansan Inhibits Neuronal Death during ER Stress by Regulating the Unfolded Protein Response

@inproceedings{Hiratsuka2010YokukansanIN,
  title={Yokukansan Inhibits Neuronal Death during ER Stress by Regulating the Unfolded Protein Response},
  author={Toru Hiratsuka and Shinsuke Matsuzaki and Shingo Miyata and Mitsuhiro Kinoshita and Kazuaki Kakehi and Shinji Nishida and Taiichi Katayama and Masaya Tohyama},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Recently, several studies have reported Yokukansan (Tsumura TJ-54), a traditional Japanese medicine, as a potential new drug for the treatment of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress is known to play an important role in the pathogenesis of AD, particularly in neuronal death. Therefore, we examined the effect of Yokukansan on ER stress-induced neurotoxicity and on familial AD-linked presenilin-1 mutation-associated cell death. METHODS We employed the WST-1… CONTINUE READING