Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers

  title={Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers},
  author={Thomas Hedner and Boo Edgar and Lars Edvinsson and Jan Hedner and Bengt Persson and Anders Pettersson},
  journal={European Journal of Clinical Pharmacology},
SummaryThe pharmacokinetics of yohimbine and its effects on sympathoadrenal function were studied in 13 young, healthy, male volunteers after an IV bolus dose of 0.25 or 0.5 mg · kg−1.Pharmacokinetic analysis showed that distribution was rapid, with a half life between 0.4 and IS min, and the elimination half life ranged between 0.25 and 2.5 h. The volume of distribution (Vss) was 741, (range 26 to 1271). Only 0.5 to 1 % of unchanged yohimbine was found in the urine, indicating that the major… 

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