Yohimbine increases plasma insulin concentrations and reverses xylazine-induced hypoinsulinemia in dogs.

@article{Hsu1988YohimbineIP,
  title={Yohimbine increases plasma insulin concentrations and reverses xylazine-induced hypoinsulinemia in dogs.},
  author={W H Hsu},
  journal={American journal of veterinary research},
  year={1988},
  volume={49 2},
  pages={
          242-4
        }
}
  • W H Hsu
  • Published in
    American journal of…
    1988
Xylazine (1.1 mg/kg of body weight, IV), an alpha 2-adrenoreceptor agonist, suppressed the increase in plasma insulin concentration induced by glucose (0.6 g/kg, IV) in dogs. Yohimbine (0.11 mg/kg, IV), an alpha 2-adrenoreceptor antagonist, given 5 minutes after xylazine, reversed effects of xylazine, whereas yohimbine alone increased plasma insulin and decreased plasma glucose concentrations. Seemingly, alpha 2-adrenoreceptors exert a negative control of insulin release. 

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