Yohimbine increases impulsivity through activation of cAMP response element binding in the orbitofrontal cortex.

@article{Sun2010YohimbineII,
  title={Yohimbine increases impulsivity through activation of cAMP response element binding in the orbitofrontal cortex.},
  author={Haosheng Sun and Thomas A. Green and David E. H. Theobald and Shari G Birnbaum and Danielle L. Graham and Fiona D. Zeeb and Eric J Nestler and Catharine A. Winstanley},
  journal={Biological psychiatry},
  year={2010},
  volume={67 7},
  pages={649-56}
}
BACKGROUND Stress can increase impulsivity and has a negative impact on psychiatric outcome. Norepinephrine is heavily implicated in responses to stress, and the alpha(2) antagonist yohimbine is used clinically to study this aspect of the stress response. Yohimbine induces mild anxiety and increases impulsivity in healthy volunteers but has more detrimental effects in some psychiatric populations, triggering mania in bipolar patients and drug craving in substance-dependent individuals… CONTINUE READING
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