Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.

  title={Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.},
  author={Edzard Ernst and M. H. Pittler},
  journal={The Journal of urology},
  volume={159 2},

Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis.

Sole administration of Yohimbine and its combination with other supplements can improve the erectile function in ED patients, however, it is not able to improve the sexual function if not combined with other treatments.

Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial

The yohimbine responders were men with less severe erectile dysfunction as manifested by improved increased rigidity on RigiScan™ testing, higher Florida Sexual Health Questionnaire scores, and slightly higher levels of serum testosterone.

Yohimbine in erectile dysfunction: the facts

  • A. Morales
  • Medicine
    International Journal of Impotence Research
  • 2000
Yohimbine, a pharmacologically well-characterized α-2-adrenoceptor antagonist with activity in the central and peripheral nervous system, has been used for over a century in the treatment of erectile dysfunction but has not yet been subjected to scientifically rigorous human clinical trials.

SOP conservative (medical and mechanical) treatment of erectile dysfunction.

An updated overview on currently used and available conservative treatment options for ED with a special focus on their efficacy, tolerability, safety, merits, and limitations including the role of combination therapies for monotherapy failures is provided.

Yohimbine: a clinical review.

Red ginseng for treating erectile dysfunction: a systematic review.

Collectively these RCTs provide suggestive evidence for the effectiveness of red ginseng in the treatment of erectile dysfunction, but the total number of R CTs included in the analysis, the total sample size and the methodological quality of the primary studies were too low to draw definitive conclusions.

Efficacy of oral sildenafil in the treatment of erectile dysfunction in diabetic men with positive response to intracavernosal injection of alprostadil.

Whether oral sildenafil citrate could be an effective alternative for the treatment of ED in diabetic men with a positive response to intracavernosal injection of alprostadil is assessed.



Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations

Results document a consistent tendency for yohimbine, and for other medications containing yohimine, to enhance erectile functioning relative to placebo.

Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction

Global assessment of erectile function applying the CGI scale revealed, beyond a placebo effect in both organic and non organic patients, a therapeutic effect in the subgroup of nonorganic patients, with a significantly greater improvement in the yohimbine group compared to the placebo group.

Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction

This double-blind, placebo-controlled clinical trial of yohimbine hydrochloride included 86 patients with erectile dysfunction and without clearly detectable organic or psychologic causes. The

The role of yohimbine for the treatment of erectile impotence.

Of 215 impotent patients subsequently treated with yohimbine, 38% reported some subjective improvement, but only 5% were completely satisfied, so the typical dose has little side effect and higher doses achieves better results, but this conclusion requires more evaluation.

Yohimbine, Erectile Capacity, and Sexual Response in Men

Mixed effects were found on measures of sexual function in men with erectile dysfunction, with 3 of 11 men reporting strong positive effects under yohimbine, as did self-assessed genital response to VSS.

Double Blind Trial of Yohimbine Hydrochloride in the Treatment of Erection Inadequacy

Yohimbine was associated with a significant improvement in the quality of stimulated erections and the drug was generally well tolerated.


Fluoxetine-induced sexual dysfunction and an open trial of yohimbine.

  • F. M. Jacobsen
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 1992
It is suggested that fluoxetine-induced sexual dysfunction may include decreased sexual desire as well as decreased physical functioning and may occur more frequently than previously appreciated and fluoxete-inducedSexual dysfunction may be treatable with yohimbine.