Yohimbine's anxiogenic action: evidence for noradrenergic and dopaminergic sites.

@article{Johnston1989YohimbinesAA,
  title={Yohimbine's anxiogenic action: evidence for noradrenergic and dopaminergic sites.},
  author={Amanda L. Johnston and S. E. File},
  journal={Pharmacology, biochemistry, and behavior},
  year={1989},
  volume={32 1},
  pages={151-6}
}
Yohimbine (2.5 or 4 mg/kg) reduced the percentage of open arm entries and the percentage of time spent on the open arms displayed by rats on an elevated plus-maze indicating anxiogenic activity. These effects were reversed by the alpha 2-adrenoceptor agonist clonidine (0.01 mg/kg) and by the dopamine receptor agonist apomorphine (0.57 mg/kg). The following failed to reverse the effects of yohimbine: the selective alpha 2-adrenoceptor agonists, guanfacine (0.25 and 1 mg/kg), B-HT920 (0.025 and 0… CONTINUE READING

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