Yin-Yang strands of PCAF/Hedgehog axis in cancer control.

  title={Yin-Yang strands of PCAF/Hedgehog axis in cancer control.},
  author={P. Diane Infante and Gianluca Canettieri and Alberto Gulino and Lucia di Marcotullio},
  journal={Trends in molecular medicine},
  volume={20 8},
PCAF (p300/CBP associated factor) harbors acetyltransferase and a recently identified ubiquitylation activity that regulates gene expression in response to genotoxic stress or mitogenic signals. We highlight the dual role of PCAF in the control of Hedgehog signaling, a master regulator of tissue development, stemness, and tumorigenesis. By promoting histone acetylation at Hedgehog/GLI1 target gene promoters or direct ubiquitylation and proteolysis of GLI1, the PCAF/GLI1 axis stands as a… CONTINUE READING
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