Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.

@article{Wang2009YinYangRO,
  title={Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.},
  author={Changhua Wang and Xiaoban Xin and Ruihua Xiang and Fresnida J. Ramos and Meilian Liu and Hak Joo Lee and Hongzhi Chen and Xuming Mao and Chintan K Kikani and Feng Liu and Lily Q. Dong},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 46},
  pages={31608-15}
}
APPL1 is a newly identified adiponectin receptor-binding protein that positively mediates adiponectin signaling in cells. Here we report that APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a negative regulator of adiponectin signaling in muscle cells. Overexpression of APPL2 inhibits the interaction between APPL1 and AdipoR1, leading to down-regulation of adiponectin signaling in C2C12 myotubes. In contrast, suppressing APPL2… CONTINUE READING
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