Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter.

@article{Sucharov2003YinY1,
  title={Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter.},
  author={Carmen C. Sucharov and Peter D. Mariner and Carlin S. Long and Michael R. Bristow and L. A. Leinwand},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 33},
  pages={31233-9}
}
Yin Yang 1 (YY1) is a transcription factor that can repress or activate transcription of the genes with which it interacts. In this report we show that YY1 is a negative regulator of the alpha-myosin heavy chain (alphaMyHC) gene, which, with betaMyHC are the molecular motors of the heart. AlphaMyHC mRNA and protein levels are down-regulated in hypertrophy and heart failure, and this is thought to be detrimental for cardiac contractility. We show that YY1 specifically interacts with the… CONTINUE READING

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