YidC is strictly required for membrane insertion of subunits a and c of the F(1)F(0)ATP synthase and SecE of the SecYEG translocase.

@article{Yi2003YidCIS,
  title={YidC is strictly required for membrane insertion of subunits a and c of the F(1)F(0)ATP synthase and SecE of the SecYEG translocase.},
  author={Liang Yi and Fenglei Jiang and Minyong Chen and Brian Cain and Albert Bolhuis and Ross E. Dalbey},
  journal={Biochemistry},
  year={2003},
  volume={42 35},
  pages={10537-44}
}
YidC was previously discovered to play a critical role for the insertion of the Sec-independent M13 procoat and Pf3 coat phage proteins into the Escherichia coli inner membrane. To determine whether there is an absolute requirement of YidC for membrane protein insertion of any endogenous E. coli proteins, we investigated a few representative membrane proteins. We found that membrane subunits of the F(0) sector of the F(1)F(0)ATP synthase and the SecE protein of the SecYEG translocase are highly… CONTINUE READING