Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination.

@article{Dichtl2002Yhh1pCft1pDL,
  title={Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination.},
  author={Bernhard Dichtl and Diana R. Blank and Martin Sadowski and Wolfgang H{\"u}bner and Stefan Weiser and W. Phillip Keller},
  journal={The EMBO journal},
  year={2002},
  volume={21 15},
  pages={
          4125-35
        }
}
RNA polymerase II (pol II) transcription termination requires co-transcriptional recognition of a functional polyadenylation signal, but the molecular mechanisms that transduce this signal to pol II remain unclear. We show that Yhh1p/Cft1p, the yeast homologue of the mammalian AAUAAA interacting protein CPSF 160, is an RNA-binding protein and provide evidence that it participates in poly(A) site recognition. Interestingly, RNA binding is mediated by a central domain composed of predicted beta… CONTINUE READING

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