Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2.

  title={Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2.},
  author={Hyun-jung Choi and Haiying Zhang and Hongryeol Park and Kyu-Sung Choi and Heon-Woo Lee and Vijayendra Agrawal and Y. -B. Kim and Young-Guen Kwon},
  journal={Nature communications},
Angiogenesis is regulated by the dynamic interaction between endothelial cells (ECs). Hippo-Yes-associated protein (YAP) signalling has emerged as a key pathway that controls organ size and tissue growth by mediating cell contact inhibition. However, the role of YAP in EC has not been defined yet. Here, we show expression of YAP in the developing front of mouse retinal vessels. YAP subcellular localization, phosphorylation and activity are regulated by VE-cadherin-mediated-EC contacts. This VE… CONTINUE READING
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