Yes-associated protein 1 regulates the stability of DeltaNp63alpha.

@article{Chatterjee2010YesassociatedP1,
  title={Yes-associated protein 1 regulates the stability of DeltaNp63alpha.},
  author={Aditi Chatterjee and Tanusree Sen and Xiaofei Chang and David Sidransky},
  journal={Cell cycle},
  year={2010},
  volume={9 1},
  pages={
          162-7
        }
}
Regulation of DeltaNp63alpha can be achieved at the transcriptional and post-translational levels, with the latter being greatly influenced by external stimuli such as DNA damaging agents. In this present study, we demonstrated that DeltaNp63alpha physical interacts with Yes-associated protein 1 (Yap1). Ectopic expression of Yap1 decreased the stability and the half-like of DeltaNp63alpha and resulted in ubiquitin-dependent degradation of DeltaNp63alpha. Further, the cisplatin mediated… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Similar Papers

Loading similar papers…