Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-β/Smad signaling

@article{Ferrigno2002YesassociatedP,
  title={Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-β/Smad signaling},
  author={O. Ferrigno and F. Lallemand and F. Verrecchia and S. L'hoste and J. Camonis and A. Atfi and A. Mauviel},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={4879-4884}
}
Members of the TGF-β family of growth factors signal from the cell surface through serine/threonine kinase receptors. Intracellular propagation of the signal occurs by phosphorylation of intracellular proteins of the Smad family. Smad7 belongs to the subclass of inhibitory Smads that function as antagonists of TGF-β signaling. A yeast two-hybrid screen of a human placental cDNA expression library using full-length mouse Smad7 as bait identified Yes-Associated Protein (YAP65) as a novel Smad7… Expand
113 Citations
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