Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin.

@article{Zhang2011YesassociatedP,
  title={Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin.},
  author={Haiying Zhang and Hilda Amalia Pasolli and Elaine Fuchs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 6},
  pages={2270-5}
}
In mammals, skin begins as a single-layered epithelium, which, through a series of signals, either stratifies and differentiates to become epidermis or invaginates downward to make hair follicles (HFs). To achieve and maintain proper tissue architecture, keratinocytes must intricately balance growth and differentiation. Here, we uncover a critical and hitherto unappreciated role for Yes-associated protein (YAP), an evolutionarily conserved transcriptional coactivator with potent oncogenic… CONTINUE READING
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