Yersinia pseudotuberculosis Spatially Controls Activation and Misregulation of Host Cell Rac1

@article{Wong2005YersiniaPS,
  title={Yersinia pseudotuberculosis Spatially Controls Activation and Misregulation of Host Cell Rac1},
  author={Ka-Wing Wong and Ralph R Isberg},
  journal={PLoS Pathogens},
  year={2005},
  volume={1},
  pages={21 - 28}
}
Yersinia pseudotuberculosis binds host cells and modulates the mammalian Rac1 guanosine triphosphatase (GTPase) at two levels. Activation of Rac1 results from integrin receptor engagement, while misregulation is promoted by translocation of YopE and YopT proteins into target cells. Little is known regarding how these various factors interplay to control Rac1 dynamics. To investigate these competing processes, the localization of Rac1 activation was imaged microscopically using fluorescence… CONTINUE READING
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