Yersinia enterocolitica invasin: a primary role in the initiation of infection.

@article{Pepe1993YersiniaEI,
  title={Yersinia enterocolitica invasin: a primary role in the initiation of infection.},
  author={Jason Pepe and Virginia L. Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 14},
  pages={6473-7}
}
The ability to invade the intestinal epithelium of mammals is an essential virulence determinant of Yersinia enterocolitica. The chromosomally encoded Y. enterocolitica 8081v invasion gene, inv, was disrupted to assess its role in pathogenesis. The inv mutant (JP273v) was approximately 80-fold less invasive than wild type for cultured epithelial cells. When mice were infected intragastrically, up to 10(7) fewer JP273v were recovered from Peyer's patches early (6-18 hr) after infection compared… CONTINUE READING
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