Yersinia enterocolitica as a vehicle for a naked DNA vaccine encoding Brucella abortus bacterioferritin or P39 antigen.

@article{AlMariri2002YersiniaEA,
  title={Yersinia enterocolitica as a vehicle for a naked DNA vaccine encoding Brucella abortus bacterioferritin or P39 antigen.},
  author={Ayman Al-Mariri and A. Rauch Tibor and Pascal Lestrate and Pascal G N Mertens and Xavier De Bolle and J Letesson},
  journal={Infection and immunity},
  year={2002},
  volume={70 4},
  pages={
          1915-23
        }
}
Brucella is a facultative intracellular parasite that causes brucellosis in animals and humans. The protective immune response against Brucella involves both humoral and cell-mediated immunity. In previous studies, we demonstrated that the T-dominant Brucella antigens bacterioferritin (BFR) and P39 administered either as CpG adjuvant recombinant proteins or as naked-DNA plasmids induced a specific Th1-biased immune response in mice. In order to improve the protection conferred by the BFR and… CONTINUE READING
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