Yersinia enterocolitica adhesin A induces production of interleukin-8 in epithelial cells.

@article{Schmid2004YersiniaEA,
  title={Yersinia enterocolitica adhesin A induces production of interleukin-8 in epithelial cells.},
  author={Yvonne Schmid and Guntram Grassl and Oliver T B{\"u}hler and Mikael Skurnik and I. Autenrieth and Erwin Bohn},
  journal={Infection and immunity},
  year={2004},
  volume={72 12},
  pages={6780-9}
}
The major invasive factor of Yersinia enterocolitica, the invasin (Inv) protein, induces proinflammatory host cell responses, including interleukin-8 (IL-8) secretion from human epithelial cells, by engagement of beta1 integrins. The Inv-triggered beta1 integrin signaling involves the small GTPase Rac; the activation of MAP kinases, such as p38, MEK1, and JNK; and the activation of the transcription factor NF-kappaB. In the present study, we demonstrate that Y. enterocolitica YadA, which is a… CONTINUE READING

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