Yeast three-hybrid-Targetidentifizierung per Klick-Chemie

Abstract

The yeast three-hybrid (Y3H) technology shows substantial potential for the identification of small molecule-target interactions in vivo. However, despite its manifold advantages as a molecular target identification method, the Y3H technique has not yet been widely used, mainly due to the challenges of synthesis of the chemical inducers of dimerization (CIDs) which are essential for this approach. Using the familiar click-technology that is able to connect molecules in an efficient and economical way, Y3H approaches can be developed into a popular target screening technology.

DOI: 10.1007/s12268-016-0752-6

Cite this paper

@article{Rizzo2016YeastTP, title={Yeast three-hybrid-Targetidentifizierung per Klick-Chemie}, author={Stefano Rizzo and Ren{\'e} Lang and J. E. Franke and Miriam Rittner}, journal={BIOspektrum}, year={2016}, volume={22}, pages={734-735} }