Yeast targets for mRNA methylation

  title={Yeast targets for mRNA methylation},
  author={Zsuzsanna Bodi and James D. Button and Donald Grierson and Rupert George Fray},
  booktitle={Nucleic acids research},
N(6)-Methyladenosine (m(6)A) is a modified base present in the mRNA of all higher eukaryotes and in Saccharomyces cerevisiae, where there is an increase in m(6)A levels during sporulation. The methyltransferase, Ime4, is responsible for this modification and has a role in the initiation of meiosis. However, neither the function, nor the extent of distribution of this nucleotide modification is established. We demonstrate that in S. cerevisiae, substantial levels of internal adenosine… CONTINUE READING
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