Yeast sirtuins and the regulation of aging.

  title={Yeast sirtuins and the regulation of aging.},
  author={Margaret B. Wierman and Jeffrey S Smith},
  journal={FEMS yeast research},
  volume={14 1},
The sirtuins are a phylogenetically conserved family of NAD(+) -dependent protein deacetylases that consume one molecule of NAD(+) for every deacetylated lysine side chain. Their requirement for NAD(+) potentially makes them prone to regulation by fluctuations in NAD(+) or biosynthesis intermediates, thus linking them to cellular metabolism. The Sir2 protein from Saccharomyces cerevisiae is the founding sirtuin family member and has been well characterized as a histone deacetylase that… CONTINUE READING
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