Yeast signal peptidase contains a glycoprotein and the Sec11 gene product.

@article{Yadeau1991YeastSP,
  title={Yeast signal peptidase contains a glycoprotein and the Sec11 gene product.},
  author={Jacques T. Yadeau and Claudette Klein and Gunter Blobel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 2},
  pages={517-21}
}
Partially purified yeast microsomal signal peptidase appears to be a complex of four polypeptides of 13, 18, 20, and 25 kDa. The 18-kDa chain is the product of the Sec11 gene, which is necessary for signal peptidase activity. The 25-kDa subunit is a glycoprotein that binds Con A. Two related methods for purification of the enzyme are presented; the first includes removal of peripheral membrane proteins from microsomes by alkali extraction, solubilization of the enzyme by nonionic detergent and… CONTINUE READING

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