Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells.

@article{Bender1986YeastPP,
  title={Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells.},
  author={Alan Bender and George F. Sprague},
  journal={Cell},
  year={1986},
  volume={47 6},
  pages={929-37}
}
We show that in yeast the cell type specificity of pheromone response is determined solely by the species of receptor that a cell synthesizes. The two receptor-pheromone interactions are functionally interchangeable and involve the creation of a common intracellular signal. In particular, we find that provision of a-factor receptor or alpha-factor receptor in mat alpha 1 mutants, which normally do not express either receptor or any other a- or alpha-specific products, allows response to the… CONTINUE READING

From This Paper

Topics from this paper.
25 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…