Yeast mutation accumulation experiment supports elevated mutation rates at highly transcribed sites.


Because mutation is the ultimate source of genetic variation, understanding mutational patterns and mechanisms is of fundamental importance. Previous studies provided geno-mic evidence that, in the bacteria Escherichia coli and Salmonella typhimurium, yeast Saccharomyces cerevisiae, and human germ line, the mutation rate of a gene generally increases with… (More)
DOI: 10.1073/pnas.1412284111


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