Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome

  title={Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome},
  author={Heiko Santelmann and John McLaren Howard},
  journal={European Journal of Gastroenterology \& Hepatology},
  • H. Santelmann, J. Howard
  • Published 1 January 2005
  • Medicine, Biology
  • European Journal of Gastroenterology & Hepatology
Many patients with irritable bowel syndrome (IBS) are disillusioned by the lack of efficacy of treatments and suffer from numerous symptoms not covered by the Rome criteria for IBS, as the current empirical treatment regimens fail to address these persistent debilitating ‘IBS associated symptoms’. These symptoms are similar to other symptom complexes like chronic fatigue and the so-called ‘candida syndrome’, and many seek help from alternative medicine. The possible role of Candida and yeasts… 

Need for a comprehensive medical approach to the neuro-immuno-gastroenterology of irritable bowel syndrome.

The organic pathophysiology of IBS is delineated, the role of inflammation is demonstrated, the possible differences between adult and pediatric IBS, the merits of a comprehensive treatment model as taught by the Institute of Functional Medicine, and the potential for future research are described.

Use of broad-spectrum antibiotics and the development of irritable bowel syndrome.

Use of broad-spectrum antibiotics--particularly macrolides or tetracyclines--may be associated with IBS development, and this study is the first to know of no other study that has associated these antibiotics with Ibs development.

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The gut nonbacterial microbiota is involved in the pathogenesis of IBS, which provides a novel perspective on the noninvasive diagnosis and precise treatment of this disease.

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The potential roles of gut mycobiome in the pathogenesis of IBS and the connections between the fungi and existing mechanisms such as chronic low-grade inflammation, visceral hypersensitivity, and brain-gut interactions are reviewed.

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Further studies are required to identify whether there is a causal link for the elevation of serum IgG found in this subgroup of patients with increased FRDQ-7 scores, or whether these two observations are parallel manifestations of a common underlying disorder.

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