Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome

@article{Santelmann2005YeastMP,
  title={Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome},
  author={Heiko Santelmann and John McLaren Howard},
  journal={European Journal of Gastroenterology \& Hepatology},
  year={2005},
  volume={17},
  pages={21-26}
}
  • H. Santelmann, J. Howard
  • Published 1 January 2005
  • Medicine, Biology
  • European Journal of Gastroenterology & Hepatology
Many patients with irritable bowel syndrome (IBS) are disillusioned by the lack of efficacy of treatments and suffer from numerous symptoms not covered by the Rome criteria for IBS, as the current empirical treatment regimens fail to address these persistent debilitating ‘IBS associated symptoms’. These symptoms are similar to other symptom complexes like chronic fatigue and the so-called ‘candida syndrome’, and many seek help from alternative medicine. The possible role of Candida and yeasts… 

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References

SHOWING 1-10 OF 78 REFERENCES

Irritable bowel syndrome and hypersensitivity to food.

TLDR
At least in atopic patients complaining of IBS, it is of importance to search for a food component, because Dramatic clinical improvements can result from the introduction of an adequate exclusion diet.

The role of faecal Candida albicans in the pathogenesis of food-intolerant irritable bowel syndrome.

TLDR
It is concluded that C. albicans is not involved in the aetiology of the irritable bowel syndrome.

Fungal-type Dysbiosis of the Gut: The Occurrence of Fungal Diseases and the Response to Challenge with Yeasty and Mould-containing Foods

TLDR
When yeast extract, leavened bread, alcoholic drinks and mould-containing cheeses were serially re-introduced into the diet, over half the patients reported recurrence of symptoms with each of the foods, but the pattern varied with different patients, few reacting to all they tested.

Candida-associated diarrhea: a syndrome in search of credibility.

  • J. LevineR. DykoskiE. Janoff
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1995
TLDR
It is concluded that Candida species may cause diarrhea in selective clinical settings because of the strong link between the abatement of diarrheal symptoms in patients for whom a significant growth of Candida was found in their stools and treatment with specific topical antifungal agents.

A randomized, double-blind trial of nystatin therapy for the candidiasis hypersensitivity syndrome.

TLDR
In women with presumed candidiasis hypersensitivity syndrome, nystatin does not reduce systemic or psychological symptoms significantly more than placebo, and the empirical recommendation of long-term nyStatin therapy for such women appears to be unwarranted.

Gut Fermentation (or the ‘Auto-brewery’) Syndrome: A New Clinical Test with Initial Observations and Discussion of Clinical and Biochemical Implications

TLDR
A new clinical test which is easy to perform is described whereby blood alcohol (EtOH) levels are measured 1 h after a 5 g glucose load in patients who have abstained from EtOH for 24 h and who have fasted for at least 3 h prior to the test.

A Comparison of Lactulose Breath Hydrogen Measurements with Gut Fermentation Profiles in Patients with Fungal-type Dysbiosis

Purpose : Fungal-type dysbiosis (FTD) is still an unproven diagnosis. Patients are polysymptomatic, but most have symptoms of irritable bowel. Treatment, using a diet low in fermentable, yeasty and

Effectiveness of nystatin in polysymptomatic patients. A randomized, double-blind trial with nystatin versus placebo in general practice.

TLDR
Nystatin is superior to placebo in reducing localized and systemic symptoms in individuals with presumed fungus hypersensitivity as selected by a 7-item questionnaire, probably enhanced even further by a sugar- and yeast-free diet.

[Gastrointestinal microecology of humans and Candida].

TLDR
In an endocrine stress model the authors found no yeasts in the duodenal juices of 7 subjects before and after stress situation, but a clear decrease of Yeast count in the faeces, indicating the formation of metabolic products by Candida is secondary to the whole of microbial fermentation in the human orointestinal tract.
...