Yeast mating pheromone activates mammalian gonadotrophs: evolutionary conservation of a reproductive hormone?

@article{Loumaye1982YeastMP,
  title={Yeast mating pheromone activates mammalian gonadotrophs: evolutionary conservation of a reproductive hormone?},
  author={Ernest Loumaye and J. Thorner and Kevin J. Catt},
  journal={Science},
  year={1982},
  volume={218 4579},
  pages={1323-5}
}
alpha-Factor, a tridecapeptide mating pheromone of yeast (Saccharomyces cerevisiae), has extensive sequence homology with the hypothalamic decapeptide gonadotropin-releasing hormone (GnRH). Both synthetic and natural preparations of alpha-mating factor were found to bind specifically to rat pituitary GnRH receptors and to stimulate the release of luteinizing hormone from cultured gonadotrophs. The ability of the yeast pheromone to reproduce the biological actions of GnRH in the mammalian… CONTINUE READING

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