Yeast lacking Cu-Zn superoxide dismutase show altered iron homeostasis. Role of oxidative stress in iron metabolism.

@article{Freitas2000YeastLC,
  title={Yeast lacking Cu-Zn superoxide dismutase show altered iron homeostasis. Role of oxidative stress in iron metabolism.},
  author={Jorge Marcelo de Freitas and Amir Liba and Rogerio Meneghini and Joan Selverstone Valentine and Edith Butler Gralla},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 16},
  pages={11645-9}
}
Saccharomyces cerevisiae lacking copper-zinc superoxide dismutase (sod1) shows a series of defects, including reduced rates of aerobic growth in synthetic glucose medium and reduced ability to grow by respiration in glycerol-rich medium. In this work, we observed that addition of iron improved the respiratory growth of the sod1 mutant and in glucose medium total intracellular iron content was higher in the sod1 mutant than in wild type cells. Transcription of the high affinity iron transporter… CONTINUE READING
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