Yeast killer toxin: site-directed mutations implicate the precursor protein as the immunity component.

@article{Boone1986YeastKT,
  title={Yeast killer toxin: site-directed mutations implicate the precursor protein as the immunity component.},
  author={Charles Boone and Howard A Bussey and Diane Greene and David Y. Thomas and Thierry Vernet},
  journal={Cell},
  year={1986},
  volume={46 1},
  pages={105-13}
}
Yeast killer toxin and a component giving immunity to it are both encoded by a gene specifying a single 35 kd precursor polypeptide. This precursor is composed of a leader peptide, the alpha and beta subunits of the secreted toxin, and a glycosylated gamma peptide separating the latter. The toxin subunits are proteolytically processed from the precursor during toxin secretion. Using site-directed mutagenesis, we have identified a region of the precursor gene necessary for expression of the… CONTINUE READING
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