Yeast histone H4 and H3 N-termini have different effects on the chromatin structure of the GAL1 promoter.

@article{FisherAdams1995YeastHH,
  title={Yeast histone H4 and H3 N-termini have different effects on the chromatin structure of the GAL1 promoter.},
  author={G Fisher-Adams and Michael R. Grunstein},
  journal={The EMBO journal},
  year={1995},
  volume={14 7},
  pages={1468-77}
}
Deletion of the histone H4 N-terminal residues 4-23 decreases activation of the GAL1 promoter as much as 20-fold, while deletion of histone H3 N-terminal residues 4-15 hyperactivates GAL1 approximately 3-fold. In an attempt to understand the mechanisms by which these two different events take place, we have examined the effects of the H4 and H3 lesions on GAL1 chromatin structure. The bacterial dam methylase, which methylates adenine residues of GATC sequences, was used as an in vivo probe for… CONTINUE READING

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