Yeast histone H4 N-terminal sequence is required for promoter activation in vivo

@article{Durrin1991YeastHH,
  title={Yeast histone H4 N-terminal sequence is required for promoter activation in vivo},
  author={L. Durrin and Randall K. Mann and P. Kayne and M. Grunstein},
  journal={Cell},
  year={1991},
  volume={65},
  pages={1023-1031}
}
  • L. Durrin, Randall K. Mann, +1 author M. Grunstein
  • Published 1991
  • Biology, Medicine
  • Cell
  • To search for histone domains that may regulate transcription in vivo, we made deletions and amino acid substitutions in the histone N-termini of S. cerevisiae. Histone H4 N-terminal residues 4-23, which include the extremely conserved, reversibly acetylated lysines (at positions 5, 8, 12, and 16), were found to encompass a region required for the activation of the GAL1 promoter. Deletions in the H4 N-terminus reduce GAL1 activation 20-fold. This effect is specific to histone H4 in that large… CONTINUE READING
    295 Citations

    Topics from this paper.

    Global and specific transcriptional repression by the histone H3 amino terminus in yeast
    • 51
    • PDF
    Solution structures of the N-terminal domain of histone H4.
    • 8
    Functional analysis of histones H2A and H2B in transcriptional repression in Saccharomyces cerevisiae.
    • 42
    • Highly Influenced
    • PDF
    A new class of histone H2A mutations in Saccharomyces cerevisiae causes specific transcriptional defects in vivo.
    • 118
    • PDF
    Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase
    • 315
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 53 REFERENCES
    Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.
    • 295
    • PDF
    Changes in histone gene dosage alter transcription in yeast.
    • 216
    • PDF
    A functional role for nucleosomes in the repression of a yeast promoter.
    • 117